Multimodality (MR/PET/CT) Monitoring Preoperative Systemic Therapy in Operable Breast Cancer
Jacobs M, Stearns V, Wolff A, Ouwerkerk R, Wahl R, Bluemke D
Johns Hopkins School of Medicine, Johns Hopkins School of Medicine
We have demonstrated the feasibility of monitoring preoperative systemic therapy in patients with operable breast cancer using multi-modality proton, sodium MR, and PET/CT imaging. Significant decrease in tumor volume, total sodium, and SUV were observed. These methods provide a basis for a comprehensive evaluation of the complex tumor environment by examining the changes in volume and sodium and glucose metabolism in response to therapy.