Blood-Tumor Permeability (K) Measured with Dynamic Contrast Enhanced MRI and C14-AIB Autoradiography in a Rat Brain Tumor Model, a Validation Study
Ferrier M, Sarin H, Thomasson D, Butman J, Fung S, Schatlo B, Gupta S, Pluta R
Dynamic contrast-enhanced MRI (DCE-MRI) data was analyzed using a direct convolution iteration method for solving equations of the general kinetic model to measure rat blood-tumor permeability. Ktrans from DCE-MRI was correlated to K1 from C14-AIB quantitative autoradiography (QAR) and found to be nearly identical. Our results validate use of this method to accurately measure permeability in rat brain tumors and suggest that it may accurately measure permeability values in human brain tumors as well.