Stimulation-induced changes in temperature and pH measured simultaneously by 1H CSI
Coman D, Trubel H, Hyder F, Sanganahalli B
In vivo measurements of brain temperature and pH in absolute units are greatly lacking in quantitative studies of function. Both temperature and pH are believed to be tightly regulated in the brain and small changes are thought to impact neurophysiology greatly. Here we demonstrate the application of a recently developed high speed 1H CSI method using a lanthanide complex to measure accurate temperature (0.05 C) and pH (0.02) distributions in the brain. Preliminary results for baseline and stimulation conditions show great sensitivity of both parameters in the cortex. Studies are underway for delivering the MR biosensor into deeper brain regions.