A Novel Approach in the Development of 19F NMR Reporter to Assess LacZ Gene Expression
Mason R, Ren R, Yu J
The University of Texas Southwestern Medical Center at Dallas
A novel class of 19F NMR lacZ gene reporter molecule (LCD-1) was designed, synthesized and tested. The successful detection with lacZ stably transfected human breast tumor MCF-7 cells shows great promise for further exploration of these reporters for in vivo assessing lacZ gene expression.