Analysis of Prostate DCE-MRI at 3T using a Measured Arterial Input Function
Turnbull L, Lowry M
University of Hull
DCE-MRI of the prostate at 3T was implemented using multiple flip angles, for T1 determination, and a rapid dynamic 3D acquisition. Pharmacokinetic analysis using a 2-comparment model and the measured arterial input function revealed that mean T1, Max [Gd], Ktrans, and Ve in tumour were significantly greater than in peripheral zone but similar to those of BPH. In addition, for all tissues, Ktrans and Ve were positively correlated with Max [Gd]. Parameter maps of Ktrans proved superior to AUC maps in delineating the extent and heterogeneity of malignancy within the prostate.