FERUMOXTRAN-10 ENHANCED MRI IN NONINVASIVE DETECTION OF LYMPH NODE METASTASES; FIRST RESULTS IN THE WORK-UP OF PROSTATE CANCER IN A CLINICAL SETTING
Daniels-Gooszen A, Heesakkers R, Van den Bosch H, Wondergem J, Koldewijn E, Hendrikx A, Barentsz J
With ferumoxtran-10 (lymphotrophic superparamagnetic nanoparticles) enhanced MRI lymph node metastases can be detected non-invasively. Sensitivity and specificity of this new technique performed in a clinical setting are evaluated. 120 consecutive patients were included. Ferumoxtran-10 enhanced MRI performed in a clinical setting of a general hospital showed a sensitivity of 89% and a specificity of 99% for the detection of lymph node metastases in prostate cancer. Additional positive lymph nodes outside the obturator fossa are found in 29%. In conclusion MRL seems a very promising and reliable technique for future workup in patients with prostate cancer.