Measuring LV-RV Interventricular Dyssynchrony using Cine DENSE MRI
Spottiswoode B, Epstein F, Meintjes E, Kramer C, Mayosi B, Patel R, Helm P, Zhong X
University of Cape Town
Cine DENSE MRI has been shown to provide a detailed mapping of mechanical activation of left ventricular (LV) myocardium. Echocardiography results show that measures of combined left and right ventricular dyssynchrony are better predictors for response to cardiac resynchronisation therapy (CRT) than LV dyssynchrony alone. In this study we adapt the cine DENSE methods to measure strain in both the LV and the right ventricle (RV). Results from normal volunteers and patients with heart failure are presented, clearly demonstrating delays to onset of strain. Cine DENSE measurements of interventricular RV-LV dyssynchrony may improve our ability to prospectively identify CRT responders.