Functional 1H NMR spectroscopy in cat visual cortex
Tkac I, Harel N, Ugurbil K
University of Minnesota
Neuronal activity in primary visual cortex of cats has been extensively investigated using different fMRI techniques. The primary goal of this study was to investigate the feasibility of determining the detection threshold for multiple brain metabolites with highly resolved in vivo 1H NMR spectroscopy in the cat visual cortex at 9.4 T. Exceptional spectral quality was achieved which allowed reliable quantification of 16 brain metabolites (CRLB < 15%). Preliminary data showed that during visual stimulation the concentration of all metabolites varied within the detection threshold range of the spectroscopic method (&[plusmn]0.2 &[micro]mol/g).