Using CASL Perfusion fMRI to Image Natural Vision
Rao H, Wang J, Tang K, Detre J, Pan W
University of Pennsylvania, Sun Yat-Sen University
Due to its noninvasive CBF quantification and long-term temporal stability, ASL perfusion fMRI provides an appealing approach for imaging brain activity during natural conditions. The present study used ASL perfusion fMRI to image brain activity when subjects were freely viewing a cartoon movie. The results revealed significant CBF increases in multiple visual pathway and frontal areas. The concurrent CBF and BOLD activities in MT showed significant associations with subjects' motion perception. These results suggest the feasibility of ASL perfusion fMRI for imaging brain activity during natural vision and support the maintained functional segregation and specialization during complex natural vision.