Assessment of pharmacokinetic parameters by different models in dynamic contrast-enhanced MRI of prostate
Jia G, Knopp M, Heverhagen J, Liang J, Levine A, Rosol T, Baudendistel K
The Ohio State University
Quantitative analysis of DCE-MRI data needs pharmacokinetic models with well mixture compartments. Different pharmacokinetic models were used for analyzing DCE-MRI data and the generated pharmacokinetic parameters were used to characterize the microcirculation in the prostate. In order to select the most appropriate pharmacokinetic model to characterize the time-signal intensity curves in prostate, this study systematically compared four available pharmacokinetic models on fitting different regions in beagle prostate by investigating the goodness-of-fit and reproducibility of the models.