Global and regional brain metabolic deficits in autism
Pavlosky W, DeVito T, Nicolson R, Williamson P, Drost D, Neufeld R, Rajakumar N
University of Western Ontario
Twenty-seven boys with autism and a control group of 30 healthy boys underwent a combined MRI/MRSI experimental protocol at 3.0 tesla. Proton metabolite amplitudes were quantified in numerous localized regions of interest, and mean global gray and white matter metabolite levels were estimated using voxel-wise partial-volume regression analysis. Patients exhibited distributed regional deficits in NAA, Glx and Myo. Global tissue-specific analysis revealed significant reduction in global gray matter NAA, Glx and Myo. Global white matter metabolite levels did not differ between groups.