T1 Measurement of Flowing Blood and Arterial Input Function Determination for Quantitative 3D T1 weighted DCE-MRI
The University of Toronto, The Hospital for Sick Children
Accurate measurement of the arterial input function (AIF) is challenging but necessary for reliable quantitative DCE-MRI. A method is proposed for accurate T1 measurement in flowing blood and simultaneous monitoring of AIF and tissue uptake of Gadomer. Results in rabbits (N=10) showed that measured pre-injection blood T1s were accurate and that individually derived AIFs followed expected biexponential decay characteristics. DCE-MRI analysis of blood volume in muscle based on individual AIFs was reliable and reproducible. The proposed method for accurate blood T1 measurement combined with reproducible AIF extraction, can greatly improve the accuracy and reproducibility of DCE-MRI analysis.