Detecting Cancer of the Bile Duct: Multivariate Analysis of 1H MRS of Bile
Bezabeh T, Albiin N, Broom U, Dolenko B, Lindberg B, Smith I, Arnelo U
NRC Institute for Biodiagnostics
Strictures in the bile duct resulting from malignant changes (cholangiocarcinoma) are difficult to distinguish from their benign counterparts, particularly in patients with primary sclerosing cholangitis (PSC), a benign chronic condition. The ability to detect early malignant changes in patients with PSC is critical in the appropriate treatment and management of these patients. 1-H MRS of bile was utilized in this study to assess the diagnostic potential of the technique. Using multivariate methods of analysis, 3 spectral regions were identified as being discriminatory and with the help of these regions; a classification accuracy of 100% was obtained in differentiating normal and PSC patients from those harboring cancer.