MR Elastography of the Liver in an Animal Model of Hepatic Fibrosis
Harris P, Torres V, Yin M, Manduca A, Ehman R
Mayo Clinic College of Medicine
At present, the gold standard for diagnosing hepatic fibrosis is liver biopsy, which is an invasive procedure, with risks of complications, potential sampling errors, and subjective histology grading problems. MR Elastography (MRE) is a modified phase-contrast MRI technique for quantitatively assessing the mechanical properties of soft tissues by visualizing propagating shear waves in soft tissues. It could be a promising non-invasive quantitative diagnostic method to assess hepatic fibrosis. Therefore, the underlying relationship between hepatic fibrosis extent and the corresponding MRE measurements of the liver tissues was quantitatively evaluated in an in vivo animal model of ARPKD mice.