Glial Glutamate Dysfunction in Schizophrenia: 13C Acetate MRS
Huntington Medical Research Institute
With our earlier 1-13C glucose MRS data, we demonstrated direct support for the role of glutamate in schizophrenia.In this study, the known glial fuel sodium acetate, enriched in carbon 1 position (2mg/kg/min over 1 hour = approximately 10g total) administered intravenously, is traced in the brain into its glial and neuronal compartments to directly determine the in vivo rates of the Krebs Cycle, glutamate-glutamine cycle and oxidative pathways. We describe reduced bicarbonate production from 1-13C acetate. We conclude glial elements of the glutamate glutamine cycle are abnormal in schizophrenic subjects.