Positive Contrast MR Imaging of Iron Oxide Nanoparticles with Simultaneous Suppression of Fat and Water Signals
Li D, Koktzoglou I, Dharmakumar R
Positive contrast imaging (PCI) has been proposed for MR imaging of spatially-dependent magnetic field differences due to the presence of iron oxide particulates. However, a major limitation with PCI in vivo is imaging in the presence of off-resonant fat. This work sought to describe the strategy of simultaneous suppression of on-resonant water and fat signals through a single pre-saturation pulse for positive contrast imaging of iron oxide particulates in the presence of fat. Imaging results in phantoms supported theoretical predictions.