Sensitivity of the vascular occupancy (VASO) method estimated using a multicompartmental blood-tissue model
Piechnik S, Jezzard P
University of Oxford
Inclusion of the measurement of cerebral blood volume (CBV) changes may enhance our understanding of functional imaging contrasts. We analyse the properties of the vascular occupancy (VASO) method to estimate relative changes in CBV through complementary changes in signal arising from the tissue. VASO depends on CBV but in a complex way, which makes it difficult to use as a marker of relative CBV changes without a-priori calibration for the resting CBV and the partial volume of tissues.