Molecular Imaging and Targeted Anti-Angiogenic Therapy in Cancer with alphanubeta3-Targeted Nanoparticles
Winter P, Caruthers S, Allen J, Williams T, Harris T, Wickline S, Lanza G
This study presents preliminary results using integrin targeted perfluorocarbon nanoparticles for targeted delivery of fumagillin (an anti-angiogenic drug) in tumor bearing rabbits with follow-on molecular imaging of angiogenesis to assess therapeutic effect. Rabbits were treated 6, 9, and 12 days after tumor implantation. Sixteen days post-implantation, fumagillin treated tumors were significantly smaller than controls. Molecular imaging of angiogenesis showed both the area and amount of MRI signal enhancement tended to be lower in treated vs. control tumors, suggesting reduced neovascular proliferation. The results of this pilot study imply that targeted fumagillin nanoparticles may suppress angiogenesis and inhibit tumor development.