Relevance of visceral adipose tissue and intrahepatic lipids in the pathogenesis of insulin resistance a cross-sectional study
Machann J, Stefan N, Hring H, Thamer C, Schndt B, Claussen C, Schick F, Fritsche A
Section on Experimental Radiology
Quantification of different lipid compartments is essential for identification of risk-factors for development of type 2 diabetes as not only the total lipid content but also its distribution is important. Aim of the study was determination of visceral adipose tissue (VAT) and intrahepatic lipids (IHL) in a cohort at increased risk for type 2 diabetes and correlation with insulin sensitivity. 180 volunteers were examined by MRI and MRS and linear correlation coefficients amounted to r=-0.61 and 0.40 for females/males for VAT and r=-0.61 and 0.51 for IHL. Both lipid compartments seem to be involved in the pathogenesis of insulin resistance.