A comparison of different methodologies to study skeletal muscle mitochondrial function in Type 2 diabetes patients
Prompers J, Nicolay K, van Loon L, Praet S, De Feyter H
Eindhoven University of Technology
Recent studies suggest that mitochondrial dysfunction plays a key role in the pathogenesis of skeletal muscle insulin resistance and Type 2 diabetes (T2D). Various experimental methods can be used to evaluate mitochondrial function. The interrelationship between in vivo 31P magnetic resonance spectroscopy (MRS) parameters of skeletal muscle mitochondrial function, whole-body spiro-ergometry and in vitro tissue markers of oxidative capacity was evaluated in T2D patients. The results of the different methods correlated well, which suggest that they all represent proper estimates of mitochondrial function in T2D patients.