Evaluation of choline concentrations in malignant breast lesions in predicting response to neoadjuvant chemotherapy
Lowry M, Manton D, Tan P, Turnbull L
University of Hull
A measurement of the in vivo T1 and T2 relaxation times of water and choline in malignant breast lesions, as well as a study using these values to obtain lesion choline concentrations and follow their changes throughout neoadjuvant chemotherapy, is reported here. We found no apparent difference in behaviour of [choline] between responsive and non-responsive lesions. This could be because [choline] is indicative of the tumour cells biological status rather than clinical response to drugs. Monitoring [choline] of malignant breast lesions therefore does not appear to be a robust way of predicting their response to chemotherapy.