Quantification of Choline-Containing Compounds in Malignant Breast Cancer by 1H Single-Voxel MR Spectroscopy at 1.5T
Baik H, Nalcioglu O, Su M, Yu H
University of California-Irvine
To investigate the feasibility of internal reference method for quantifying the Cho concentrations in patients with malignant breast tumors using a clinical 1.5T scanner, and to compare the Cho concentration range measured with the current method with previously published results. We have performed single-voxel MR spectroscopy and demonstrated the potential of the method for the absolute quantification of Cho metabolite in malignant breast lesions. The Cho levels from 28 spectra (82 %) were in a range of 0.76 ?10.22 mmol/kg, which seems to be consistent with previously published value (i.e., 0 ?10 mmol/kg).