How Accurately Can the Diffusion Profiles Predict Multiple Fiber Orientations? - A Study on General Fiber Crossings in Diffusion MRI
Yang Y, Zhan W
National Institute on Drug Abuse, NIH
High angular resolution diffusion (HARD) imaging and q-space imaging techniques have been developed to identify intravoxel multi-fiber components, based on the measured profiles of apparent diffusion coefficient (ADC) and orientation distribution function (ODF), respectively. The exact relationship between local maxima of the diffusion profiles and the actual orientations of fibers is crucial for accurate determination of the fiber orientation, but has not yet been systematically investigated. The present study aims to examine the accuracy of these profile-based methods by directly comparing the angular deviations between the estimated local maxima of the profiles and the real fiber orientations under various conditions.