Age-related changes in cerebral white and grey matter structures from infancy to adulthood: a voxel-based morphometry study
Connelly A, Groeschel S, Vollmer B
UCL Institute of Child Health
In order to quantify and localise morphometric changes during brain development structural high resolution MRI data of 159 subjects from birth to 30 years of age were analysed using voxel-based morphometry. The total volumes of both grey and white matter increase non-linearly over this age range. Relative to brain size, overall grey matter volume decreases non-linearly over this age range, whereas overall relative white matter volume increases. Regression analyses with age as a covariate have been performed during childhood, adolescence, and young adulthood, revealing regional changes in tissue concentration and volume both in grey and white matter structures.