Relative Cerebral Blood Volume is a Measure of Angiogenesis in Brain Tuberculoma and Its Therapeutic Implications
Gupta R, Haris M, Husain N, Husain M, Prasad K, Pauliah M, Srivastava C, Tripathi M, Rastogi M, Bihari S, Rathore D, Rathore R
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Dynamic contrast enhanced (DCE) MRI has been performed in 15 patients with (9 excised and 6 follow-up) brain tuberculomas. The relative cerebral blood volume in case of excised tuberculoma correlated significantly with cellular component and histopathologically derived microvascular density (MVD) and vascular endothelial growth factor (VEGF). In case of follow-up patients, there was significant decrease in cellular component at three time points with significant decrease in relative cerebral blood volume (rCBV) in response to anti-tuberculous therapy. We conclude that rCBV is a surrogate marker of angiogenesis in brain tuberculoma.