Registration of MALDI mass spectrometry images and MR parametric maps for relaxomic analysis
Luci J, Sinha T, Dawant B, Gore J, Cornett D, Shahidi S
The work presented here explores the accurate alignment of tissue proteomic imaging via MALDI mass spectrometry (MS) and MR imaging. The goal is to provide a cohesive imaging study where each voxel in the image volume is a multivariate signal of various MR parameters (R1, R2, qMT, etc.) and tissue protein composition as determined by MS imaging. We demonstrate a comprehensive registration protocol to align MALDI MS images to corresponding locations in MR parametric spaces.