Logitudinal in vivo DTI assessment of contusion injury and secondary degeneration in mouse spinal cord.
Kim J, Song S
Longitudinal DTI was performed to assess injury progression of the residual ventrolateral white matter in contusion injured mouse spinal cord. The temporal and spatial evolution of secondary injury in white matter was clearly observed via the RA time course. The time courses of axial and radial diffusivity further suggest that axonal injury preceded demyelination in the white matter of this contusion spinal cord injury model. Longitudinal measurements in vivo reduce derived parameter uncertainty caused inter-animal differences when measurements are made ex vivo at single time points.