THALAMIC AND HIPPOCAMPAL DYSFUNCTION IN TLE MEASURED BY MRS
Vives K, Spencer D, Kuzniecky R, Pan J, Hetherington H
Recent work by Pan has demonstrated that there are significant declines in energetics (PCr/ATP) in the contralateral hippocampus, thalami and basal ganglia of patients with temporal lobe epilepsy. This finding supports the role of an anatomical network of involved structures in the pathophysiology of temporal lobe epilepsy. Previously, Kuzniecky reported that decrements in NAA in the contralateral hippocampus were associated with seizure recurrence following temporal lobectomy. In this work we demonstrate that decreases NAA in the network are: 1) anatomically correlated and 2) can they be used to lateralize the focus and predict surgical outcome.