Efficient 19F imaging of Multi-Spectral-Line Contrast Agents: Aliasing serves to minimize time encoding
Keupp J, Schaeffter T
Philips Research Laboratories
19F MR imaging allows direct quantification of nano-particles or fluorinated (anti-cancer) drugs for molecular imaging. However, 19F MR imaging is generally complicated by chemical shift artifacts induced by multi-line spectra with a shift range of around 100 ppm. Many counter measures have been described which typically lead to reduced SNR (line selection/saturation) or long imaging time (chemical shift encoding). A time encoding scheme with minimum number of equidistant encoding steps is proposed and demonstrated in a phantom study, which combines all spectral lines in a single image with optimized SNR and scan efficiency.