In vivo quantification of neuronal degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 mapping
Heinze H, Sander K, Angenstein F, Niessen H, Scheich H, Vielhaber S
University of Magdeburg
G93A-SOD1 transgenic mice are used as an animal model to study the pathogenesis and the efficacy of drugs in amyotrophic lateral sclerosis (ALS). Here, we used T2 mapping in the brain to monitor motor neuron degeneration at early stages of ALS. Depending on the disease progression, ALS mice showed significantly increased T2 values in brain stem motor nuclei Nc. V, VII, XII, and spinal cord, whereas no change was observed in motor cortex and thalamus. Consequently, the parameter T2 can be applied as a magnetic resonance progression marker that may allow for the screening of putative treatments of ALS.