Regional T1 Relaxation Time and Tissue Content Changes of Hippocampus in Bipolar Disorder
Chu W, Strakowski S, Hetherington H, Adler C, DelBello M, Lee J
Univ. of Cincinnati
The mood dysfunction that is present in bipolar disorder (BD; manic depressive illness) patients could be related to the abnormalities in specific brain regions that modulate emotion. The changes of gray matter content in amygdale have been reported in several BD studies. The reported studies of hippocampus, which also is an important region involved in mood disorders, are few. The present work investigated the tissue content changes (gray and white matters, and cerebral spinal fluid) in hippocampus in BD patients, and healthy volunteers using T1-relaxation-time-based tissue segmentation methods.