Enhanced T2 contrast for MR Histology of the mouse brain
Johnson G, Sharief A
Duke University Medical Center
T2-weighted contrast in the mouse brain at high fields has been a challenge due to the degrading effects of diffusion- and susceptibility- induced losses. This work illustrates a robust 3D CPMG sequence capable of producing isotropic 43-micron resolution T2-weighted images of the actively stained mouse brain at 9.4T. The signal and contrast is further enhanced with the application of a Fourier transform along the temporal dimension. The results show a detailed visualization of mouse brain structures like multiple cortical layers and thalamic nuclei not reported before in T2-weighted acquisitions.