High Field MRI Demonstrates Global Brain Iron Overload in Aceruloplasminemia
Schenck J, Zimmerman E, Henderson D
GE Global Research
For the first time 3T MRI is reported along with quantitative T2 values for the rare genetic iron-storage disease aceruloplasminemia. A striking decrease in T2 is found throughout the brain including the thalamus, white matter and hippocampus. This suggests that in other neurodegenerative diseases it may be useful to investigate the possibility of iron-dependent T2 changes in regions not normally associated with iron accumulation.