Does repeated injections of an iron-based contrast agent lead to an accumulation of iron in the brain parenchyma?
VALABLE S, BARBIER E, SEGEBARTH C, REMY C
U594, Univ grenoble 1
Vessel Size Index (VSI) MRI technique aims at providing data on the microvasculature. To date, is has been applied only at a unique time point. We aimed to verify if VSI imaging could be done at different time points. Rat bearing tumors received multiple injections of Sinerem and the evolution of the VSI was assessed. In the contralateral side, no variations of VSI were observed. Histological analysis revealed no accumulation of iron in the brain. In the tumor, we observed an increase of the VSI as a function of time. In conclusion, VSI imaging could be used to follow the evolution of the vasculature.