Sensitivity of voxel-based analysis of DTI images to the warping strategy
Briellmann R, Pardoe H, Pell G, Abbott D, Jackson G
Brain Research Institute
Voxel-based analysis has become a popular method for the quantitative analysis of changes in DTI parameters between subject groups. It relies on the warping of the images from different subjects to a common space. However, there is no consensus as to how to best perform this warping step. In a study of subjects with epilepsy, the data was analysed using eight alternative warping strategies. The areas of fractional anisotropy change are shown to vary greatly with the warping step, while the Trace changes were relatively consistent. Results reported with this technique should be interpreted in this light and appropriate regard taken of the chosen warping procedure.