Regional Variability of Aging and Gender Difference in Human Corpus Callosum: a Diffusion Tensor MRI study at 4 Tesla
Zhang Y, Jahng G, Du A, Weiner M, Schuff N
UC San Francisco and Center for Imaging of Neurodegenerative Diseases (CIND), VA Medical Center
4 Tesla MRI and Diffusion Tensor Tractography were used to study age and gender related fractional anisotropy (FA) and mean diffusivity (MD) changes in the corpus callosum (CC). FA decreased with age in anterior CC and MD increased with age in anterior and body CC, while age effect on posterior CC wasnt detected. In addition, a trend of higher FA values in women than in men was found in anterior CC. The results indicate that healthy aging is associated with diminished fiber integrity in anterior CC, which may help to better understand the topology of age-associated brain alterations.