BOLD Deactivation Response to Hand Tapping in Multiple Sclerosis Patients
Manson S, Polman C, Miller D, Montalban X, Palace J, Rocca M, Ropele S, Thompson A, Rovira A, Smith S, Thornton J, Yousry T, Wegner C, Barkhof F, Agosta F, Beckmann C, Ciccarelli O, De Stefano N, Gass A, Hirsch J, Frank J, Fazekas F, Filippi M, Mancini L, Korteweg T, Johansen-Berg H, Kappos L, Marino S, Manfredonia F
Oxford University, National Institutes of Health
Many conclusions about cortical reorganization within the multiple sclerosis brain have been previously drawn from BOLD activation data. Here we use the deactivation contrast (rest minus task) to draw clinically relevant conclusions about reorganization in multiple sclerosis. Additionally, our multi-centre study exhibits that it is possible to get consistent data amongst multiple sites.