Extraction of Pharmacokinetic Parameters from Human Brain Cocaine BOLD Responses
Risinger R, Kufahl P, Bloom A, Li S
Medical College of Wisconsin
Cocaine activation of the orbitofrontal cortex, ventral striatum and dorsal caudate in cocaine-dependent human subjects was observed with the BOLD signal. The transient deflections from baseline (pre-cocaine infusion) levels were modeled with a single-compartment pharmacokinetic model. Parameters from this model were numerically determined and used to estimate cocaine absorption and clearance in brain tissue. Variability of these parameters associated with experimental conditions and consistency with the pharmacology literature were assessed.