Rate of Myocardial Contrast Enhancement with Extracellular Contrast Agent and Relationship to Perfusion Reserve
Stillman A, Rickers C, Murthy N, Jerosch-Herold M
Cleveland Clinic Foundation, University of Minnesota
The rate of myocardial contrast enhancement is sensitive to changes in myocardial blood flow, but this relationship has not been systematically investigated. Starting with the central volume principle we derive an approximation between blood flow and rate of contrast enhancement, which is used to estimate the myocardial perfusion reserve, a clinically important parameter for assessing the hemodynamic signifcant of coronary lesions.