Delineation of ischemically injured myocardium on T1 weighted MRI after intravenous injection of SHU555A
Krombach G, Bcker A, Gnther R, Dehles M, Temur Y
University Hospital Aachen
The SPIO SHU555A was intravenously injected in 7 pigs with acute reperfused myocardial infarction. T1 values of left ventricular blood, ischemically injured and remote myocardium were repeatedly measured over an observation period of 3 hours. The T1 value of ischemically injured myocardium gradually decreases from 875 61 ms to 588 54 ms (remote myocardium 787 31 ms prior injection and 759 22 ms, 3 hours after injection of SHU 555A). ANOVA showed a significant difference of regional T1 for remote myocardium and infarcted myocardium, starting 60 min after injection of SHU555A. SHU555A has the potential for delineating the spatial extent of ischemically injured myocardium stably over a time period of at least two hours.