4D Mouse Cardiac Isotropic Black-Blood Imaging for Phenotyping
Bishop J, Feintuch A, Davidson L, Bruneau B, Henkelman R, French B, Epstein F, Berr S
Hospital for Sick Children
The mouse cardiac imaging environment differs from the human one in several factors. These include a much shorter cardiac cycle longer scan time possibilities and consequently less sensitivity to respiration. In that context, this study demonstrates how to perform 4D whole heart imaging which is optimized for segmentation and phenotyping analysis. A black-blood protocol is used for enhanced tissue-blood contrast combined with a MOTSA technique for full heart coverage. The effectiveness of this method is demonstrated on a mutant mouse.