Hyperpolarized 129Xe Human Pulmonary Gas Exchange with 3-point Dixon Technique
Patz S, Muradian I, Topulos G, Butler J, Ketel S, Russet I, Hersman F, Covrig S, Hrovat M
Brigham and Women's Hospital
Magnetic Resonance images of human pulmonary gas exchange, i.e. diffusion of gaseous hyperpolarized 129Xe from the alveolar gas space into the parenchymal tissue, were obtained. Here we report a direct measurement of both the gas and tissue signals and their ratio, which gives the fraction of gas exchanged into tissue during a specified exchange time. This ratio is also proportional to a functional parameter of the lung, local surface area per unit volume S/V.