MRI Assessment of Renal Function During Percutaneous Transluminal Angioplasty of Renal Artery Stenosis in Swine
Li D, Park J, Rhee T, Omary R, Larson A, Schirf B, Cashen T, Shin W, Carroll T, Prasad P
Northwestern University, Northwestern University Feinberg School of Medicine
We tested the hypothesis that MRI can successfully detect changes in renal function at the time of renal percutaneous transluminal angioplasty (PTA) in a swine model of renal artery stenosis (RAS). Before and after X-ray-guided PTA, pigs were imaged on a 3.0 T MR scanner to obtain functional kidney measurements. Glomerular filtration rate (GFR), extraction fraction (EF), and the renal blood flow (RBF) were measured pre- and post-procedure. Increases in GFR and EF following PTA were statistically significant, but changes in RBF were not. This combined X-ray/MR approach is now possible in a clinical setting with new hybrid X-ray/MR scanners.