MR Guided Percutaneous Intramyocardial Injection of Contrast Medium Solution to Infarct Borders after Delineation of the Infarct with High Molecular Contrast Media: Measurement of T1 Values
Krombach G, Temur Y, Pfeffer J, Hohl C, Bcker A, Gnther R, Kinzel S
University Hospital Aachen
In 12 pigs reperfused myocardial infarction was induced. SHU 555A or MS325 were intravenously injected in order to delineate the infarct. After sufficient contrast between infracted and remote myocardium was obtained, intramyocardial injection was stared. The borders of the infarct were selected as target areas. Real-time MR imaging allowed for advancing a needle catheter from a carotid artery sheath into the left ventricle, inserting it into the myocardium, and injecting a Gd-DTPA-BMA solution. The described technique is a promising tool for minimally invasive percutaneous delivery of substances and visualization of their distribution.