Temporal and Spatial Evolution of MR derived cerebral metabolic rate of oxygen utilization index in acute Middle Cerebral Artery Occlusion Stroke rats
An H, Chang L, Lin W, Chen Y
University of North Carolina at Chapel Hill
In this study, the temporal and spatial evolution of MR measured cerebral metabolic rate of oxygen utilization index (MR-COMI) was studied during acute stage and its correlation with the final tissue outcome defined by 24 hours T2 images after MCAO was examined in a middle cerebral artery occlusion rat model. Lesions recruited to final infarction usually have a substantial reduction in MR_COMI, while the reversible lesions with compromised acute CBF but without final T2 lesions only show modest reduction in MR_COMI and comparable MR_COMI were obtained in the ipsi- and contra-lateral hemisphere in rats without CBF/T2 lesion.