High resolution sodium imaging of rat and mouse models of stroke at 17.6 T
Webb A, Neuberger T
PENN STATE UNIVERSITY, UNIVERSITY OF WUERZBURG
This work presents the first in vivo high resolution sodium images acquired from two different mouse model of stroke, as well as one for rat. Submillimeter voxel sizes were achieved using density weighted chemical shift imaging techniques at high field. Localization of the infarct from the sodium images agreed well with those from T2- and diffusion-weighted proton imaging. Measurement of the sodium T1 relaxation times showed slightly higher values in the infarcted region of the mouse brain than for normal tissue, with excellent reproducibility during the study.