Study of Ocular Drug Delivery Using Contrast-Enhanced Magnetic Resonance Imaging
Wang N, Lutz R, Csaky K, Robinson M, Lizak M, Tansey G, Galban C, Kim S
University of Maryland
Contrast enhanced (CE)-MRI was utilized to determine the effects of various barriers and clearances in ocular drug delivery. Gd-DTPA was administered in vivo by continuous infusion into rabbit eyes and spatial and temporal distributions of Gd-DTPA in various ocular tissues were obtained. Resulting scans show that effective ocular drug delivery requires high infusion rates of drug to achieve delivery to the posterior regions of the eye and sustained infusion to minimize loss through rapid retinal clearance.