Extraction of the Contribution of the First Bolus Passage to the Signal in Dynamic Perfusion Measurements
Gall P, Speck O, Strecker R, Kiselev V
University Hospital Freiburg
Dynamic perfusion measurements are based on the tracer dilution theory, that uses the signal of the first bolus passage of an injected tracer. In a circular flow, the injected bolus will appear repeatedly at the observation point. In order to use the tracer dilution theory, the first bolus passage has to be isolated from the recirculatory contributions. In this work, a new method for the first bolus passage extraction is presented and compared to the commonly used gamma variate fit approach.