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Abstract #1574

Permeability Fitting of DSC Perfusion Data through Constrained Optimization

Tasciyan T
Medical Numerics Inc

A fitting method is described to simultaneously determine the CBV and permeability transfer and rate constants with a total of 5 parameters using the Marquardt Levenberg algorithm with additional constraints. The results demonstrate the robustness of the fitting process and the reliability of the constraints in ensuring that the primary contribution to the overall fit is from the bolus term and not from the leakage.