Reproducibility of 1H-MR spectroscopic imaging in the centrum semi-ovale in patients with multiple sclerosis
Hoogduin H, De Keyser J, van der Grond J, Mostert J
University Medical Center Groningen, University of Groningen
The reproducibility of 1H-MR spectroscopic imaging at the centrum semi-ovale over a time span of 4 weeks was investigated in clinically stable MS patients. NAA/Cr ratios were reproducible with a coefficient of variation of 5.3 and 3.9% in gray and white matter, respectively. This indicates that 1H MR spectroscopic imaging can potentially be used as a surrogate marker in MS.